Just like Tooth Mousse, Tooth Mousse Plus is applied topically to at-risk surfaces. This can be done by first cleaning the teeth and then smearing a small amount of Tooth Mousse Plus across the tooth surfaces with a clean finger or cotton-tipped applicator. When applied immediately before bed, the material is then left in place, to dissolve slowly overnight. It is not rinsed out. Tooth Mousse Plus can also be applied topically to the teeth using a custom-made tray such as a pull-down tray made for applying a whitening gel.